Cleavage ep 3

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Rb is known to play an important role in regulating apoptosis. Rb may also control the function of p53 through binding MDM2. Previous studies have shown that interleukin 1-converting enzyme ICE -like proteases are important in pmediated apoptosis and that activation of caspase-3 appears at an early step of apoptosis Kim et al. Saudi Journal of Biological Sciences Abstract The p16 tumor suppressor gene is frequently inactivated in human cancer tissues and cell lines. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

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cleavage ep 3

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Activation of caspase-3 and cleavage of Rb are associated with pmediated apoptosis in human non-small cell lung cancer cells. Thus, inactivation of MDM2 may enhance p53 functions such as G 1 arrest and apoptosis. The E1A-deleted adenovirus vector dl was used as a control vector.

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